該基因編碼屬于與染色質重塑相關的鋅指DNA結合蛋白家族的轉錄因子。這種蛋白的表達僅限于胎兒和成人的血液淋巴細胞生成系統，并作為淋巴細胞分化的調節器。一些選擇性剪接轉錄變異體編碼不同亞型已被描述為這個基因。大多數亞型共享一個共同的C端結構域，其中包含兩個鋅指基序，這兩個基序是異二聚或同二聚以及與其他蛋白質相互作用所必需的。然而，這些亞型在結合DNA的N末端鋅指基序的數量和核定位信號的存在上有所不同，從而導致具有或不具有DNA結合特性的成員。只有少數亞型含有必需的三個或更多的N末端鋅基序，這些基序賦予靶基因啟動子中特定核心DNA序列元件高親和力結合。非DNA結合亞型主要存在于細胞質中，被認為是顯性負性因子。某些顯性陰性亞型的過度表達與B細胞惡性腫瘤有關，如急性淋巴細胞白血病（ALL）。
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).