這個基因是腫瘤壞死因子超家族的成員編碼的跨膜蛋白的主要功能是通過與fas結合誘導細胞凋亡。Fas/FasLG信號通路是免疫系統調節的關鍵，包括T細胞的活化誘導的細胞死亡（AICD）和細胞毒性T淋巴細胞誘導的細胞死亡。它也與一些癌癥的進展有關。該基因缺陷可能與系統性紅斑狼瘡（sle）有關。另外，已經描述了剪接轉錄變體。[由RefSeq提供，2014年11月]
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]