pole4是一種組蛋白折疊蛋白，與其他組蛋白折疊蛋白相互作用，以序列獨立的方式結合DNA。這些組蛋白折疊蛋白二聚體結合在較大的酶復合物中，用于DNA轉錄、復制和包裝。
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.