該基因編碼一種定位于核仁的轉錄終止因子，在核糖體基因轉錄中起關鍵作用。編碼蛋白通過與前rRNA編碼區下游的sal盒終止因子結合來介導RNA聚合酶I轉錄的終止。另外，還觀察到該基因編碼多種亞型的剪接轉錄變體。該基因與另一個基因NK2同源盒1（也稱為甲狀腺轉錄因子1）共享符號/別名“tff1”，后者在甲狀腺特異性基因表達的調節中起作用。
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.